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Filopodyan: An open-source pipeline for the analysis of filopodia

Overview of attention for article published in Journal of Cell Biology, July 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
41 tweeters
facebook
6 Facebook pages

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
52 Mendeley
Title
Filopodyan: An open-source pipeline for the analysis of filopodia
Published in
Journal of Cell Biology, July 2017
DOI 10.1083/jcb.201705113
Pubmed ID
Authors

Vasja Urbančič, Richard Butler, Benjamin Richier, Manuel Peter, Julia Mason, Frederick J. Livesey, Christine E. Holt, Jennifer L. Gallop

Abstract

Filopodia have important sensory and mechanical roles in motile cells. The recruitment of actin regulators, such as ENA/VASP proteins, to sites of protrusion underlies diverse molecular mechanisms of filopodia formation and extension. We developed Filopodyan (filopodia dynamics analysis) in Fiji and R to measure fluorescence in filopodia and at their tips and bases concurrently with their morphological and dynamic properties. Filopodyan supports high-throughput phenotype characterization as well as detailed interactive editing of filopodia reconstructions through an intuitive graphical user interface. Our highly customizable pipeline is widely applicable, capable of detecting filopodia in four different cell types in vitro and in vivo. We use Filopodyan to quantify the recruitment of ENA and VASP preceding filopodia formation in neuronal growth cones, and uncover a molecular heterogeneity whereby different filopodia display markedly different responses to changes in the accumulation of ENA and VASP fluorescence in their tips over time.

Twitter Demographics

The data shown below were collected from the profiles of 41 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 27%
Researcher 9 17%
Student > Bachelor 8 15%
Student > Doctoral Student 6 12%
Student > Master 4 8%
Other 11 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 29%
Biochemistry, Genetics and Molecular Biology 11 21%
Neuroscience 7 13%
Unspecified 5 10%
Medicine and Dentistry 3 6%
Other 11 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2018.
All research outputs
#588,523
of 12,465,758 outputs
Outputs from Journal of Cell Biology
#337
of 9,553 outputs
Outputs of similar age
#23,587
of 262,904 outputs
Outputs of similar age from Journal of Cell Biology
#13
of 94 outputs
Altmetric has tracked 12,465,758 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,553 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,904 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.